UVRAG Polyclonal Antibody
Catalog No. Size
Format: Peptide affinity-purified antibody in PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
Autophagy is a catabolic process that results in the degradation of bulk cytoplasmic contents within autophagosomes and lysosomes. UV radiation resistance-associated gene product (UVRAG) is a protein localized in the endoplasmic reticulum (ER) and endosomes and is known to regulate autophagosome maturation as well as early stages of autophagy. UVRAG regulates autophagosome maturation by binding to the homotypic fusion and vacuole protein sorting (HOPS) complex, which consists of the class C Vps complex (Vps11-Vps16-Vps18-Vps33) and two additional proteins, Vps39 and Vps41. UVRAG binding to the HOPS complex stimulates lysosomal fusion with autophagosome and endosome.
Antigen: Synthetic peptide corresponding to mid-protein amino acids of human UVRAG.
Accession no. NP_003360.2 Gene ID 7405 SwissProt Q9P2Y5
Host Species: Rabbit
Specificity: This antibody recognizes human and rat UVRAG.
Immunoblotting: use at 1- 2ug/ml. A band of ~75- 90kDa is detected.
Immunofluorescence: use at 10ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.