Anti-RICK (CT) Antibody
Catalog No.: 2183
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
A CARD-containing serine/threonine kinase has been identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively. RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induces apoptosis and activates NF- B and JNK. RICK interacts with members of the TRAF family, CLARP, and caspase-1. RICK regulates TNF and Fas induced-apoptosis and is involved in the generation of the proinflammatory cytokine IL-1 . The mRNA of RICK is expressed in many human tissues.
Antigen: Synthetic peptide corresponding to aa 508-522 of human RICK (accession no. AF027706).
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human, mouse, and rat RICK (60kDa).
Immunoblotting : use at 1-2ug/ml.
Positive control: A431 cell lysate.
Immunocytochemistry: use at 5ug/ml.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.