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Anti-P95/NBS1 (Phospho-Ser343) Antibody (43057)

$366.00

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ul WB Human
SKU: 43057 Categories: ,
Overview
Product Name Anti-P95/NBS1 (Phospho-Ser343) Antibody (43057)
Description Anti-P95/NBS1 (Phospho-Ser343) Rabbit Polyclonal Antibody
Target P95/NBS1 (Phospho-Ser343)
Species Reactivity Human
Applications WB
Host Rabbit
Clonality Polyclonal
Immunogen Peptide sequence that includes phosphorylation site of Serine 343 (S-L-S(p)-Q-G) derived from human p95/NBS1.
Properties
Form Liquid
Concentration 1.0 mg/mL
Formulation PBS (without Mg2 and Ca2 ), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Buffer Anti-Microbial 0.02% Sodium Azide
Buffer Cryopreservative 50% Glycerol
Format Purified
Purification Affinity-purified on phosphopeptide; non-phosphopeptidereactive antibodies were removed by chromatography on non-phosphorylated peptide
Specificity Information
Specificity This antibody detects endogenous human p95/NBS1 only when phosphorylated at serine 343.
Target ID P95/NBS1 (Phospho-Ser343)
Post Translational Modification P95/NBS1 (Phospho-Ser343)
Target Phospho-ser343
Research Areas Phosphospecific Antibodies
Background Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Application Images
Additional Information
Handling
Storage This antibody is stable for at least one (1) year at -20°C.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting: use at dilution of 1:500-1:1,000. A band of ~95kDa is detected.

These are recommended working dilutions.

End user should determine optimal dilutions for their application.
References & Data Sheet