Catalog No.: 1107
Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma-tography.
Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates which mediates the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF, and insulin receptors, has been identified in human and mouse. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP). p62dok, along with p56dok, represents a new family of RasGAP-binding proteins.
Antigen: Peptide corresponding to aa 425- 439 of human p62dok.
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human p62dok (62kD).
Immunoblotting: use at 1:1,000-1:2,000 dilution.
Positive control: Whole cell lysate of Jurkat cells.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.