Anti-NKX3.1 Antibody (NT)
Catalog No.: 34013
Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
NKX3.1 is a homeobox gene which exhibits prostate- and testis-specific expression. Loss of NKX3.1 expression has been implicated in prostate development and tumorigenesis. NKX3.1 expression is dramatically down-regulated in testicular cancer of germ cell origin. Results suggest that NKX3.1 is essential for normal testis function and that its loss of expression is highly associated with the invasive phenotype of testicular germ cell tumors.
Immunogen: Synthetic peptide corresponding to aa residues 21-37 (TPSKPLTSFLIQDILRD) of human NKX3.1 conjugated to KLH at the C- terminus.
Host Species: Rabbit
Preservatives: None. Available on request.
This antibody recognizes human NKX3.1 (approx. 26 kDa). This sequence is highly conserved in rat and mouse.
Immunoblotting : use at 1:1,000
Positive control: Human prostate tissue extracts.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Lind GE. et al. (2005) Mol Cancer. 4:8.
Gelmann E.P. et al. (2003) Prostate 55:111-117.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.