Anti-Interleukin-21 Receptor (IL-21R) (ED) Antibody (40104)

$445.00

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ug ELISA,WB,IHC-P,IF Human
SKU: 40104 Categories: , ,
Overview
Product Name Anti-Interleukin-21 Receptor (IL-21R) (ED) Antibody (40104)
Description Anti-IL-21R (ED) Rabbit Polyclonal Antibody
Target Interleukin-21 Receptor (IL-21R) (ED)
Species Reactivity Human
Applications ELISA,WB,IHC-P,IF
Host Rabbit
Clonality Polyclonal
Immunogen Peptide corresponding to aa 97-111 of human IL-21R precursor.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by peptide immuno-affinity chromatography
Specificity Information
Specificity This antibody recognizes human IL- 21R, the receptor for IL-21. IL-21R complexes with the common cytokine receptor g chain, gc, and mediates IL-21 signaling. IL-21 and its receptor activate the JAK-STAT signaling pathway. IL-21R is expressed in spleen and thymus as well as on natural killer (NK), T and B cells and plays a role in the proliferation and maturation of these cell populations.
Target Name Interleukin-21 receptor
Target ID Interleukin-21 Receptor (IL-21R) (ED)
Uniprot ID Q9HBE5
Alternative Names IL-21 receptor, IL-21R, Novel interleukin receptor, CD antigen CD360
Gene Name IL21R
Sequence Location Membrane; Single-pass type I membrane protein.
Biological Function This is a receptor for interleukin-21.
Research Areas Growth Factors, Cytokines, Receptors
Application Images
Description Western blot analysis of IL-21 receptor expression in human HepG2 cell lysate with IL-21 receptor antibody at (A) 1 and (B) 2 ug/ml.
Description Immunohistochemistry of IL-21 receptor in rat lung with IL-21 receptor antibody at 10 ug/mL.
Description Immunofluorescence of IL-21 Receptor in Rat Lung cells with IL-21 Receptor antibody at 20 ug/mL.
Description Immunofluorescence of IL21R in A431 cells with IL 21 Receptor antibody at 20 ug/mL. Green: IL-21 Receptor Antibody (40104)
Blue: DAPI staining
Additional Information
Handling
Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting: use at 0.5-1 ug/mL. In immunoblots, a band of 60 kD is detected.

Positive control: Raji cell lysate.
References & Data Sheet