Anti-Influenza B Neuraminidase Antibody (19602)

$596.00

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 500ug ELISA,Neutralization Influenza B Neuraminidase
SKU: 19602 Categories: , ,
Overview
Product Name Anti-Influenza B Neuraminidase Antibody (19602)
Description Anti-Influenza B Neuraminidase Mouse Monoclonal Antibody
Target Influenza B Neuraminidase
Species Reactivity Influenza B Neuraminidase
Applications ELISA,Neutralization
Host Mouse
Clonality Monoclonal
Clone ID B14
Isotype IgG2a
Immunogen Influenza B HK/73.
Associated Products
Associated Clone Specificity Notes

19601

Lee/40

3.92

Md/1/59

3.22

HK/8/73

1.93

Sing/222/79

3.20

Ore/5/80

2.62

USSR/100/83

<

Mem/3/89

<

19602

3.06

3.21

3.40

3.34

4.02

2.24

2.02

19603

<

3.25

3.53

2.94

3.60

<

<

Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by Protein G affinity chromatography
Specificity Information
Specificity 19601 = Influenza B Lee/40;19602, 19603 = Influenza B HK/73.
Target Name Neuraminidase
Target ID Influenza B Neuraminidase
Uniprot ID P03474
Alternative Names EC 3.2.1.18
Gene Name NA
Sequence Location Virion membrane, Host apical cell membrane
Biological Function Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication. {HAMAP-Rule:MF_04071}.
Research Areas Infectious Disease
Application Images
Description Neuraminidase Inhibition Titers Against Influenza B Isolates
Additional Information
Handling
Storage These antibodies are stable for at least one (1) year at -20 to-70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions These antibodies may be used in immunoassays to detect and quantitate Influenza B neuraminidase and in neuraminidase inhibition assays.
References & Data Sheet
References G.M. Air et al. (1990) Virology 177: 578. (Catalog no. 19601 = MAb B3, 19602 = MAb B14, 19603 = MAb B19).
PMID 1695410