GFAP Monoclonal Antibody
Catalog no.: 56566 (clone S206A-8)
Format: 100ug (1mg/ml) Protein G-purified antibody in PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.
Glial fibrillary acidic protein (GFAP) is a major structural component of astrocytes. Phosphorylation of GFAP, and its association with annexin II-p2 and S-100, regulates GFAP polymerization. One of the first events that occurs during astrocyte proliferation is increased GFAP expression. Antibodies to GFAP have been detected in individuals with dementia, although the significance of this has not been conclusively determined.
Antigen: Synthetic peptide corresponding to aa 411-422 (KTVEMRDGEVIK) of human GFAP. This sequence is 100% identical to rat and mouse.
Accession nos.: NP_001124491.1, P14136
Gene ID: 2670
Host Species: Mouse
Antibody Class: IgG1
Specificity: This antibody recognizes human, mouse and rat GFAP. It cross-reacts with GFAP- R416W and other GFAP mutant proteins.
Immunoblotting: use at 1-4ug/ml. A band of ~50kDa is detected.
Immunofluorescence: use at 10ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their application.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This product is stable for at least one (1) year at -20°C.
For in vitro investigational use only. Not intended for therapeutic or diagnostic procedures.