Anti-APRIL (ED) Antibody (41000)

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ug ELISA,WB Human, Drosophila
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Overview
Product Name Anti-APRIL (ED) Antibody (41000)
Description Anti-APRIL (ED) Rabbit Polyclonal Antibody
Target APRIL (ED)
Species Reactivity Human, Drosophila
Applications ELISA,WB
Host Rabbit
Clonality Polyclonal
Immunogen Peptide corresponding to aa 50-100 of human APRIL.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, 0.02% sodium azide.
Buffer Formulation Phosphate Buffered Saline
Buffer Anti-Microbial 0.02% Sodium Azide
Format Purified
Purification Purified by peptide immuno-affinity chromatography
Specificity Information
Specificity Human APRIL. Reactivity with other species has not been investigated.
Target Name Tumor necrosis factor ligand superfamily member 13
Target ID APRIL (ED)
Uniprot ID O75888
Alternative Names A proliferation-inducing ligand, APRIL, TNF- and APOL-related leukocyte expressed ligand 2, TALL-2, TNF-related death ligand 1, TRDL-1, CD antigen CD256
Gene Name TNFSF13
Sequence Location Secreted
Biological Function Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. {PubMed:10973284}.
Research Areas Growth Factors, Cytokines, Receptors
Background APRIL (A Proliferation-Inducing Ligand) is a member of the TNF superfamily identified in human and mouse. Two receptors for APRIL have been designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its receptors BCMA and TACI are involved in autoimmunity and cancer.
Application Images
Description Western blot analysis of APRIL expression in K562 cells with APRIL antibody at (A) 5 and (B) 10 ug/mL.
Additional Information
Handling
Storage This antibody is stable for three months at 4°C and at least one year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting: use at 5-10 ug/mL. A band of ~27kDa is detected.
References & Data Sheet