Angiotensin Converting Enzyme 2 (ACE2) Polyclonal Antibody
Catalog No.: 19506
Size: 100ul (1.2mg/ml)
Format: Antigen affinity-purified antibody in PBS, pH 7.3, 50% glycerol, 0.05% sodium azide.
Angiotensin-converting enzyme 2 (ACE2) is a zinc containing metalloenzyme located on the surface of endothelial and other cells in the lungs, arteries, heart, kidney, and intestines. The primary function of ACE2 is to offset activity of angiotensin-converting enzyme (ACE). ACE cleaves angiotensin I into the vasoconstrictor angiotensin II. ACE2 in turn cleaves angiotensin II into the vasodilator angiotensin 1–7. In addition, ACE2 is the main entry point into cells for some coronaviruses including HCoV-NL63, SARS-CoV (the coronavirus that causes SARS) and SARS-CoV-2 (the coronavirus that causes COVID-19). More precisely, the binding of the spike S1 protein of SARS-CoV and SARS-CoV2 to the enzymatic domain of ACE2 on the surface of cells results in endocytosis and translocation of both the virus and the enzyme into endosomes located within cells.
Antigen: Fusion protein corresponding to internal residues of human ACE2.
Accession no.: Q9BYF1
Gene ID: 59272
Host Species: Rabbit
Specificity: Human ACE2.
Immunohistochemistry: use at dilution of 1:25-1:100.
Detection of ACE2 in paraffin-embedded human brain with #19506 diluted 1:30.
Detection of ACE2 in paraffin-embedded human thyroid carcinoma with #19506 diluted 1:30.
These are recommended dilutions. Endusers should determine optimal dilutions for their applications.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.