Anti-FBG4 Antibody (28105)
$384.00
| Host | Quantity | Applications | Species Reactivity | Data Sheet | |
|---|---|---|---|---|---|
| Rabbit | 100ug | WB,ELISA | Human |  |
Overview
Product Name Anti-FBG4 Antibody (28105)
Description Anti-FBG4 (F Box 4) Rabbit Polyclonal Antibody
Target FBG4
Species Reactivity Human
Applications WB,ELISA
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to amino acids 70-85 (LQLARDRSAEGRALYA) of human FBG4 conjugated to KLH at the N- terminus.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by peptide immuno-affinity chromatography
Specificity Information
Specificity This antibody recognizes amino acids human FBG4. Sequence homology to mouse and rat FBG4 protein is 100%.
Target Name F-box only protein 17
Target ID FBG4
Uniprot ID Q96EF6
Alternative Names F-box only protein 26
Gene Name FBXO17
Biological Function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.
Research Areas Neuroscience
Background F-box proteins, critical components of the conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F- box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Novel human F-box proteins named FBG1, FBG2, FBG3, FBG4 and FBG5 constitute a subfamily of mammalian F-box proteins. FBG genes are expressed in a limited number of human tissues including kidney, liver, brain and muscle tissues.
Handling
Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting : use at 1:500 dilution. A band of approximately 31 kDa is detected.
Positive control: recombinant human full length FBG4 protein.
Positive control: recombinant human full length FBG4 protein.
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