Anti-Factor XII Heavy Chain Antibody (19801)

$538.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Mouse	250ug	WB,ELISA,AP,Coagulation Assays	Human

SKU: 19801 Categories: Antibody Products, Coagulation Factor Antibodies, Factor XII Antibodies, Products

Overview

Product Name Anti-Factor XII Heavy Chain Antibody (19801)

Description Anti-Factor XII Heavy Chain Mouse Monoclonal Antibody

Target Factor XII Heavy Chain

Species Reactivity Human

Applications WB,ELISA,AP,Coagulation Assays

Host Mouse

Clonality Monoclonal

Clone ID B7C9

Isotype IgG1

Immunogen Purified human Factor XII.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by Protein G affinity chromatography

Specificity Purified human Factor XII.

Target Name Coagulation factor XII

Target ID Factor XII Heavy Chain

Uniprot ID P00748

Alternative Names EC 3.4.21.38, Hageman factor, HAF [Cleaved into: Coagulation factor XIIa heavy chain; β-factor XIIa part 1; Coagulation factor XIIa light chain

Gene Name F12

Sequence Location Secreted.

Biological Function Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. {PubMed:21304106}.

Research Areas Coagulation factors.

Handling

Storage These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.

Application Instructions This antibody may be used in ELISA, Western blot, coagulation assays and for immunopurification of Factor XII.

References Pixley et al. (1987) J Biol Chem 262: 10140.

PMID 2440859

Data Sheet