Catalog No.: 34016
Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma-tography.
WW domain-containing oxidoreductase, WWOX, also known as WOX1 or FOR, is a proapoptotic protein expressed by a tumor suppressor gene. Because mutation or deletion in the coding region of WWOX is rarely found, it is speculated that the appearance of aberrant transcripts affects progression of many cancers. In addition, protein levels of WWOX, its Tyr33- phosphorylated form, and WOX2 are significantly down-regulated in the neurons of Alzheimer’s hippocampi.
Immunogen: Synthetic peptide corresponding to amino acids 89-107 (RLAFTVDDNPTKPTTRQRY) of human WWOX conjugated to KLH at the C- terminus.
Host Species: Rabbit
Preservatives: None. Available on request.
This antibody recognizes human and mouse WWOX. Sequence identity to chimpanzee and orangutan WWOX is 100%.
Immunoblotting : use at 1:5,000 dilution. A band of approximately 46 kDa is detected.
Positive control: MCF-7 human breast cancer cell lysate or murine fibroblast L929 cell lysate.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Chang, N.S et al. Oncogene (2005) 24: 714-723.
Aqeilan, R.I. et al. Cancer Res (2004) 64: 8256-8261.
Sze, C.I. et al. J Biol Chem (2004) 279: 30498-30506.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.