Varicella-Zoster Virus Antigen (BA104VS)

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Host Quantity Applications Species Reactivity Data Sheet  
1mg Immunoassays Varicella-Zoster
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Overview
Product Name Varicella-Zoster Virus Antigen (BA104VS)
Description For production of the two native antigens VZV Antigen (BA104VS) and VZV Glycoprotein (BA104VSG) HEL 299 cells are infected with VZV strain Ellen. After cultivation, the antigens are purified by ultra-centrifugation through a sucrose cushion (BA104VS) or detergent extracted and purified via lectin affinity chromatography (BA104VSG). VZV antigen BA104VS is recommended for IgM detection, while glycoprotein BA104VSG is very well suited for IgG assays.
Species Reactivity Varicella-Zoster
Applications Immunoassays
Source Varicella zoster virus, strain Ellen, HEL 299 cell culture
Properties
Formulation 100 mM glycine buffer, pH 9.5
Buffer Formulation 100 mM Glycine
Buffer pH pH 9.5
Format Liquid
Background Varicella zoster virus (VZV), a member of the Herpesviridae family also known as Human Herpesvirus Type 3 (HHV-3), is a highly contagious virus causing varicella (chickenpox) after primary infection. Transmission occurs via droplets and aerosols or contact with virus containing vesicles or scabs. Polymorphic exanthemas with a strong itch leading to papulation, vesicles and eschar are typical for this childhood disease. In healthy children, chickenpox is a usually harmless and self-limiting infection. However, lifelong latency in cranial nerve and dorsal root ganglia is usually established and reactivation as herpes zoster (shingles) may occur decades after primary infection. Primary infection of adults, especially of immunosuppressed patients, or newborns may be fatal and infection during gestation can lead to congenital varicella syndrome. Thus, VZV serological tests are commonly used for confirmation of acute infection, control of vaccination effectiveness and in some countries they are even routinely added to TORCH screening of pregnant women. Furthermore, VZV serology is an important diagnostic element in the context of transplantation, because immunocompromised patients have an increased risk for severe complications after infection or virus reactivation.
Specificity Information
Specificity Varicella-Zoster Virus Antigen
Research Areas Infectious Disease
Application Images
Additional Information
Handling
Storage Store at -65°C or lower. Avoid repeated freeze-thaw cycles. Sonicate before use. 10 years from date of manufacture (under recommended storage conditions).
References & Data Sheet