Anti-TrpC5 Ca+2 Channel Monoclonal Antibody
Catalog No.: 11541 (clone S67-15)
Size: 100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. TrpC5 (transient receptor potential cation channel, subfamily C, member 5) is a subtype of the TrpC family of mammalian transient receptor potential ion channels. Homomultimeric TrpC5 and heteromultimeric TrpC5-TrpC1 channels are activated by extracellular reduced thioredoxin. This activation has been associated with rheumatoid arthritis as well as with action on anesthetics such as chloroform, halothane, and propofol.
Antigen: Synthetic peptide corresponding to aa 827-845 of human TrpC5 (accession no. Q9UL62).
Host Species: Mouse
Antibody Class: IgG2b
This antibody recognizes human, mouse, and rat TrpC5.
Immunoblotting: use at 1-10ug/ml. A band of ~110kDa is detected.
Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml
Immunofluorescence: use at 1-10ug/ml
These are recommended concentrations. User should determine optimal concentrations for their application.
Positive control: Rat brain lysate.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid repeated freezing and thawing.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.