Anti-Thyroglobulin Antibody (12103)

$215.00 – $430.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Mouse	100ug	ELISA	Human

Quantity

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SKU: 12103 Categories: Antibody Products, Hormones and Serum Protein Antibodies, Products

Overview

Product Name Anti-Thyroglobulin Antibody (12103)

Description Anti-Thyroglobulin Mouse Monoclonal Antibody

Target Thyroglobulin

Species Reactivity Human

Applications ELISA

Host Mouse

Clonality Monoclonal

Clone ID TG8.1

Isotype IgM

Immunogen Purified human thyroglobulin

Associated Products This antibody is included in the following Library Pack containing multiple antibodies:

121101 - Anti-Thyroglobulin Mouse Monoclonal Antibody - Library Pack

This antibody is associated to the following antibodies of similar specification:

12101 - Anti-Thyroglobulin Antibody - Clone TG60 - Isotype IgG1
12102 - Anti-Thyroglobulin Antibody - Clone TG62 - Isotype IgG1
12104 - Anti-Thyroglobulin Antibody - Clone TG9.1 - Isotype IgG1

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by protein G affinity chromatography

Target Name Thyroglobulin

Target ID Thyroglobulin

Uniprot ID P01266

Alternative Names Tg

Gene Name TG

Sequence Location Secreted

Biological Function Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030). {PubMed:17532758, PubMed:32025030}.

Research Areas Hormones/Proteins

Handling

Storage These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Dilution Instructions Dilute in PBS or medium which is identical to that used in the assay system.

Application Instructions These antibodies may be used in ELISA to detect and quantitate thyroglobulin.

Data Sheet