Tau

 Tau 

ORDERING INFORMATION 

Catalog no.: 57012 

Format: 100ug (1mg/ml) Protein G-purified antibody in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol. 

BACKGROUND 

Tau is a subunit protein of one of the major markers of Alzheimer disease (AD), the neurofibrillary tangles. Tau protein has many unusual properties, such as its number of structural conformations and biochemical modifications (phosphorylation, proteolysis, and glycosylation), and its many interaction partners (mainly microtubules, but also other cytoskeletal proteins, kinases, and phosphatases, motor proteins, chaperones, and membrane proteins). The aggregation of Tau is toxic in cell and animal models, but can be reversed by suppressing expression or by aggregation inhibitors. 

SPECIFICATION SUMMARY 

Antigen: Full-length recombinant human Tau441 (2N4R) P301S mutant protein pre-formed fibrils. In humans, mutation P301S gives rise to early-onset dementia. 

Accession no.: P10636 

Gene ID: 4137 

Host Species: Mouse 

Clone no.: 1D5 

Antibody subtype: IgG1 

Specificity: This antibody recognizes human, mouse, and rat Tau. 

APPLICATIONS 

Immunoblotting: use at 1-5ug/ml. A band of ~45.8kDa is detected. 

Detection of Tau in 10ug of lysate of T-47d breast cancer cells (lane 2) and 20ug of mouse brain (lane 3) with #57012 at 1ug/ml. 

These are recommended concentrations. Endusers should determine optimal concentrations for their applications. 

DILUTION INSTRUCTIONS 

Dilute in PBS or medium that is identical to that used in the assay system. 

STORAGE AND STABILITY 

This product is stable for at least one (1) year at -20°C. 

For in vitro investigational use only. Not intended for therapeutic or diagnostic procedures. 

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