TASK1 Potassium Channel

TASK1 Potassium Channel Monoclonal Antibody

ORDERING INFORMATION

Catalog no.: 11578 (clone S374-48)
Format: 100ug (1mg/ml) Protein G-purified antibody in PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.

BACKGROUND

TASK1 channels are members of the two-pore domain family of potassium channels whose structure consists of two pore-forming regions flanked by four membrane-spanning domains. The activity of these channels is sensitive to changes in extracellular pH in the physiological range. Like other two-pore domain family members, these channels show little time or voltage dependence. Thus they have characteristics of leak K+ channels, generating background currents that contribute to membrane potential and the shaping of cell excitability.

SPECIFICATION SUMMARY

Antigen: Fusion protein corresponding to aa 251-411 (cytoplasmic C-terminus) of rat TASK1. This sequence is 96% identical in mouse, 76% identical in human, and <30% identical in TASK3. Accession nos: NP_203694.1, O54912 Gene ID: 29553 Host Species: Mouse Antibody Class: IgG2b Specificity: This antibody recognizes human, mouse, and rat TASK1.

APPLICATIONS

Immunoblotting: use at 1-5ug/ml. A band of ~50kDa is detected.
Immunofluorescence: use at 10ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their application.

DILUTION INSTRUCTIONS

Dilute in PBS or medium that is identical to that used in the assay system.

STORAGE AND STABILITY

This product is stable for at least one (1) year at -20°C.

For in vitro investigational use only. Not intended for therapeutic or diagnostic procedures.