Survivin (CT)

Anti-Survivin (CT) Antibody

ORDERING INFORMATION

Catalog No.: 2235
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

BACKGROUND

Apoptosis can be prevented by the inhibitor of apoptosis proteins (IAPs). IAPs constitute a conserved gene family that binds to and inhibits cell death proteases. A novel IAP has been identified and designated Survivin. Survivin interacts with the processed form of caspase-3 and inhibits its proteolytic activity. Survivin is expressed predominantly in tissues of embryos, transformed cell lines, and many human cancers.

SPECIFICATION SUMMARY

Antigen: Peptide corresponding to aa 129- 142 of human Survivin (accession no. NP_001159).
Host Species: Rabbit
Stabilizers: None
Preservatives: 0.02% sodium azide.

SPECIFICITY

This antibody recognizes human Survivin (17kDa).

APPLICATIONS

Immunoblotting: use at 1ug/ml.
Positive control: MOLT4 cell lysate.
Immunocytochemistry: use at 10ug/ml.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

DILUTION INSTRUCTIONS

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE AND STABILITY

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

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