Superoxide Dismutase 1 (SOD1) EDI Polyclonal Antibody
Catalog No.: 13064
Format: 100ug (1mg/ml) peptide affinity-purified antibody in PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme that catalyzes the dismutation of the superoxide radical O2- to oxygen and hydrogen peroxide which are then metabolized to H2O and O2 by catalase and glutathione peroxidase. SODs play an important role in antioxidant defense mechanisms. Three different SOD isoenzymes are found in mammalian cells: SOD1, SOD2, and SOD3. SOD1 contains Cu and Zn ions and exists as a homodimer in cell cytoplasm. The two subunits of ~16kDa each are linked by two cysteines that form an intra- subunit disulfide bridge. Misfolding of SOD1 has been implicated in Amyotrophic Lateral Sclerosis (ALS).
Antigen: Synthetic peptide corresponding to exposed dimer interface (EDI) region at the N- terminus of SOD1.
Accession no.: CAG46542, P00441
Gene ID: 6647
Host Species: Rabbit
Specificity: This antibody recognizes human, mouse, and rat SOD1.
Immunoblotting: use at 1ug/ml. A band of ~18kDa is detected.
These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C.
For in vitro investigational use only. Not intended for diagnostic or therapeutic applications.