Superoxide Dismutase 1 (SOD1) Unfolded Beta Barrel Polyclonal Antibody
Catalog No.: 13065
Format: 100ug (1mg/ml) Protein A-purified antibody in PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme that catalyzes the dismutation of the superoxide radical O2- to oxygen and hydrogen peroxide which are then metabolized to H2O and O2 by catalase and glutathione peroxidase. SODs play an important role in antioxidant defense mechanisms. SOD1 contains Cu and Zn ions and exists as a homodimer in cell cytoplasm. Each SOD1 monomer folds into an eight-stranded “Greek key” beta-barrel. These strands are connected by seven external loops. Misfolding of SOD1 has been implicated in Amyotrophic Lateral Sclerosis (ALS).
Antigen: Synthetic peptide corresponding to unfolded beta barrel (UβB) region at the N-terminus of SOD1.
Accession no.: CAG46542, P00441
Gene ID: 6647
Host Species: Rabbit
Specificity: This antibody recognizes a conformation-specific epitope where the beta barrel is unfolded.
Immunoblotting: use at 1ug/ml. A band of ~18kDa is detected.
Immunofluorescence: use at 10ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C.
For in vitro investigational use only. Not intended for diagnostic or therapeutic applications.