Sphingosine kinase type 1 Polyclonal Antibody
Catalog No.: 13810
Size: 50ug peptide immunogen affinity purified antibody in PBS containing 0.1% sodium azide.
Sphingosine kinase (SPHK) phosphorylates sphingosine to form a bioactive lipid, sphingosine 1-phosphate (S1P). S1P is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival while extracellularly it is a ligand for endothelial differentiation gene 1 (EDG1). Expression of SPHK1 and subsequent production of S1P promotes the G1-S transition, protects cells from apoptosis, stimulates migration and angiogenesis, and induces tumor formation in mice.
Antigen: Synthetic peptide conjugated to KLH.
Host Species: Rabbit
Preservatives: 0.1% sodium azide
This antibody recognizes an epitope within the N-terminal domain of human SPHK1.
Immunohistochemistry: Use at 10ug/ml.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable at 4°C (short- term) and -70°C (long-term).
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.