SIRP alpha Polyclonal Antibody
Catalog No.: 2428
Format: 100ug (1mg/ml) peptide affinity-purified antibody in PBS, 0.02% sodium azide.
Protein tyrosine phosphatases (PTPases), such as SHP-1 and SHP-2, are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation, or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was cloned from human, rat, mouse, and cattle by several laboratories and was designated SIRPα, SHPS-1, and MyD-1. SIRPα/SHPS-1 is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR, and src, and is a specific docking protein for SHP-2. SIRPα/SHPS-1 has regulatory effects on cellular responses and plays a general role in different physiological and pathological processes.
Antigen: Synthetic peptide corresponding to 17 amino acids within the last 50 amino acids at the C-terminus of human SIRPα.
Accession no.: NP_542970
Gene ID: 140885
Host Species: Rabbit
Specificity: This antibody recognizes human SIRP alpha 1, 2, and 3.
Immunoblotting: use at 0.5-2ug/ml. A band of 75-110kDa is detected.
Immunocytochemistry: use at 1-5ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable at 4˚C for three months and for at least one year at -20˚C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not intended for therapeutic or diagnostic applications.