Secretogranin II Polyclonal Antibody
Catalog No.: 26107
Format: 100ug peptide affinity-purified rabbit IgG (2mg/ml)
Secretogranin II (SgII), encoded by the gene SCG2, is a member of the granin family of neuroendocrine secretory proteins. The granin family also includes chromogranin A (CgA), chromogranin B (CgB), and several other secretogranin-like proteins. Studies in rodents suggest that the full-length protein, SgII, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. SgII occurs in a variety of neoplasms arising from endocrine and neuroendocrine cells and can be a useful histological tumor marker for those cells.
Antigen: Synthetic peptide derived from the N-terminus of mature SgII protein: QRNQLLGKEPDLRLENVQK (Accession no. AAA36607).
Host Species: Rabbit
Specificity: This antibody recognizes human, rat, and squirrel monkey SgII.
Immunoblotting: use at 0.5-1.0ug/ml.
Immunohistochemistry: use at 2-5ug/ml.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C to -70°C. Avoid repeated freeze-thaw cycles.
Vasauskas AA et al. 2011. Regulation and distribution of squirrel monkey chorionic gonadotropin and secretogranin II in the pituitary. General and Comparative Endocrinology 170: 509-513.
For in vitro investigational use only. Not intended for diagnostic or therapeutic applications.