Anti-RICK (NT) Antibody
Catalog No.: 2427
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
A CARD-containing serine/threonine kinase that regulates apoptosis has been identified and designated RICK (RIP-like interacting CLARP kinase). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. RICK kinase domain has high sequence homology to that of RIP. Overexpression of RICK promotes the activation of caspase-8 and Fas-induced apoptosis. RICK represents a novel kinase that regulates Fas induced- apoptosis. The messenger RNA of RICK is expressed in a variety of human tissues.
Antigen: Synthetic peptide corresponding to aa 11-30 at the N-terminus of human RICK (accession no. O43353).
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes full-length human, mouse, and rat RICK (60kDa).
Immunoblotting: use at 1ug/ml.
Positive control: A431 or K562 cell lysate.
Immunocytochemistry: use at 10ug/ml.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.