Mikrogen Diagnostik recomLine HSV-1 & HSV-2 IgG Lateral Strip Test Kit (5372)
$450.00
| Host | Quantity | Applications | Species Reactivity | Data Sheet | |
|---|---|---|---|---|---|
| 20 Tests | Lateral Strip Assay | Herpes Simples Virus 1 and Herpes Simples Virus 2 |  |
Overview
Product Name Mikrogen Diagnostik recomLine HSV-1 & HSV-2 IgG Lateral Strip Test Kit (5372)
Description Strip-Immunoassay with antigens produced by recombinant techniques for the detection and differentiation of IgG antibodies against HSV-1 und HSV-2. Markers include:
HSV-Lysate
IgG-1
IgG-2
HSV-Lysate
IgG-1
IgG-2
Target Human Herpes Simples Virus 1 and Human Herpes Simples Virus 2 IgG
Species Reactivity Herpes Simples Virus 1 and Herpes Simples Virus 2
Assay Type Indirect Sandwich ELISA
Applications Lateral Strip Assay
Properties
Background The herpes simplex viruses (HSV) belong to the most widespread disease pathogens in the world. There are two serotypes, HSV-1 and HSV-2, which are very similar serologically, however their clinical manifestations are different. In order for an infection to result, direct contact with tissue or secretions containing virus is necessary.
The two serotypes generally prefer different sites of infection, but in principle can infect any area of the skin. In this respect, HSV-1 is primarily responsible for diseases in the area of the head such as herpes labialis (herpes simplex of the lips), while HSV-2 is responsible for diseases in the genital and anal area, such as herpes genitalis (genital herpes) . Severe rare manifestations include, for example, HSV-associated encephalitis or herpes corneae. HSV infection of the newborn (herpes neonatorum), which can occur during or shortly after birth, has particularly severe consequences.
The primary contact with HSV-1 occurs during childhood; that of HSV-2, in contrast, only after the first sexual contact as a young adult [3]. The sero-prevalence increases with increasing age and is markedly higher for HSV-1 that for HSV-2.
Most HSV test kits on the market, including those claiming to detect HSV type-1 or type-2, are based on crude antigen preparations that react equally well with antibodies from HSV-1 and HSV-2 infected patients. As most of the adults already have acquired an HSV-1 infection (seroprevalence is about 83% in Germany) the serological status for HSV-2 can not be reliably proved by crude HSV virus lysate based tests.
The recomLine HSV-1 & HSV-2 IgG uses purified, subtype specific recombinant gG1 (HSV-1) and gG2 (HSV-2) antigens and therefore assures the correct differentiation between an HSV-1 and HSV-2 infection.
The two serotypes generally prefer different sites of infection, but in principle can infect any area of the skin. In this respect, HSV-1 is primarily responsible for diseases in the area of the head such as herpes labialis (herpes simplex of the lips), while HSV-2 is responsible for diseases in the genital and anal area, such as herpes genitalis (genital herpes) . Severe rare manifestations include, for example, HSV-associated encephalitis or herpes corneae. HSV infection of the newborn (herpes neonatorum), which can occur during or shortly after birth, has particularly severe consequences.
The primary contact with HSV-1 occurs during childhood; that of HSV-2, in contrast, only after the first sexual contact as a young adult [3]. The sero-prevalence increases with increasing age and is markedly higher for HSV-1 that for HSV-2.
Most HSV test kits on the market, including those claiming to detect HSV type-1 or type-2, are based on crude antigen preparations that react equally well with antibodies from HSV-1 and HSV-2 infected patients. As most of the adults already have acquired an HSV-1 infection (seroprevalence is about 83% in Germany) the serological status for HSV-2 can not be reliably proved by crude HSV virus lysate based tests.
The recomLine HSV-1 & HSV-2 IgG uses purified, subtype specific recombinant gG1 (HSV-1) and gG2 (HSV-2) antigens and therefore assures the correct differentiation between an HSV-1 and HSV-2 infection.
Sample Type Serum, plasma, whole blood
Assay Resolution See Figure
Components
| 10X Wash Buffer | 100 mL |
| TMB Substrate | 40 mL |
| Milk Powder | 5 g |
| Instuctions for Use | 1 Each |
| Evaluation Form | 1 Each |
| Test Strips | 2 Vials x 10 Each |
| Anti-Human IgG Conjugate | 500 uL |
| Positive Control | 140 uL |
| Negative Control | 140 uL |
Specificity Information
Target Name Herpes simplex 1 and Herpes simple 2 markers: HSV whole lysate, gG-1, gG-2
Target ID Human Herpes Simples Virus 1 and Human Herpes Simples Virus 2 IgG
Alternative Names HSV whole lysate, gG-1, gG-2
Research Areas Infectious Disease
Application Images
Description Test Strip Layout
Description Test Principle
Description Evaluation
Additional Information
Additional Information Additional Mirkogen Kit Information
Handling
Storage Store at 2 - 8°C until expiration on packaging.
References & Data Sheet
Data Sheet 
Download PDF Data Sheet
Download PDF Data Sheet