Mikrogen Diagnostik recomLine HEV IgG/IgM Lateral Strip Test Kit (5072)

$600.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
	20 Tests	Lateral Strip Assay	Hepatitis E Virus

SKU: 5072 Categories: Infectious Disease Test Kits and Positive Controls, Positive Control Sera, Test Kits, VirionSerion ELISA

Overview

Product Name Mikrogen Diagnostik recomLine HEV IgG/IgM Lateral Strip Test Kit (5072)

Description Strip immunoassay with recombinant antigens for the detection of IgG or IgM antibodies against Hepatitis E virus (HEV) in human serum or plasma. Markers include:

ON2-Gt1

ON2-Gt3

O2M

O2C-Gt1

O2C-Gt3

O3-Gt1

O3-Gt3

Target Human Hepatitis E Virus IgG/IgM

Species Reactivity Hepatitis E Virus

Assay Type Indirect Sandwich ELISA

Applications Lateral Strip Assay

Properties

Background Hepatitis E virus (HEV) is one of the most common causes of faecal-orally acquired hepatitis in developing countries world-wide, usually resulting from contaminated drinking water. In recent years reports of sporadic HEV infections in industrialised countries without travel-association have been more frequent, often with a subclinical or asymptomatic course. Almost all of these so-called autochthonous cases of hepatitis E are associated with genotype 3 of HEV which shows a high sequence-homology to genotype 3 isolates from pigs. The possibility of a zoonotic infection from pigs or other animals to humans seems to play a role as well as the transmission from person-to-person through contaminated foods or blood products.

Acute hepatitis E is a severe illness with a comparable clinical presentation to hepatitis A. Typical signs of hepatitis E include flu-like symptoms, vomiting, diarrhoea, fever, arthralgia and headache usually associated with a rise in liver enzyme values. Cholestatic jaundice that develops during the course of disease can persist for several weeks. HEV infection is usually self-limiting. In endemic regions in a high percentage of cases HEV infections during pregnancy follow a fulminant course, accompanied by a high mortality rate of approx. 20%. In males and non-pregnant females the mortality rate is 0.5% - 4.0%.

The recomLine HEV IgG/IgM uses purified recombinant antigens, thus guaranteeing reproducibly high sensitivity and specificity. The selection of homologous proteins from two different genotypes (genotype 1 and genotype 3) provides a high sensitivity also in non-endemic areas with a high percentage of autochthonous cases of hepatitis E.

Sample Type Serum, plasma, whole blood

Assay Resolution See Figure

Components

10X Wash Buffer	100 mL
TMB Substrate	40 mL
Milk Powder	5 g
Instuctions for Use	1 Each
Evaluation Form	1 Each
Test Strips	2 Vials x 10 Each
Anti-Human IgG Conjugate	500 uL
Positive Control	140 uL
Negative Control	140 uL

Target Name Hepatitis virus markers: n-terminal HEV Capsid Proteins (gentotype 1, genotype 3), Middle HEV Capsid protein (genotype 1), C-terminal HEV Capsid protein (genotype 1, genotype 3), ORF 3 HEV protein (genotype 1, genotype 3)

Target ID Human Hepatitis E Virus IgG/IgM

Alternative Names ON2-Gt1, ON2-Gt3, O2M, O2C-Gt1, O2C-Gt3, O3-Gt1, O3-Gt3

Research Areas Infectious Disease