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Mikrogen Diagnostik recomLine Helicobacter IgG 2.0 Lateral Strip Test Kit (4774)

Host Quantity Applications Species Reactivity Data Sheet  
20 Tests Lateral Strip Assay Helicobacter
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Overview
Product Name Mikrogen Diagnostik recomLine Helicobacter IgG 2.0 Lateral Strip Test Kit (4774)
Description Line immunoassay using recombinant antigens for the detection and differentiation of IgG or IgA antibodies against Helicobacter pylori type I and type II. Includes markers:

CagA

VacA

GroEL

FliD

HpaA

gGT

HtrA

NapA

HP231

CtkA
Target Human Helicobacter IgG
Species Reactivity Helicobacter
Assay Type Indirect Sandwich ELISA
Applications Lateral Strip Assay
Properties
Background The gram-negative, microaerophilic bacterium was described in 1983 by Warren and Marshall. It colonises the human stomach and is able to persist there in the long term. Approx. 50% of all humans worldwide are infected with Helicobacter pylori. While all those infected develop a chronic inflammation of the gastric mucosa, this leads to complaint symptoms only in a part of the patients. The Helicobacter pylori infection is believed to be linked to various gastric disorders, such as gastric ulcers, gastric adenocarcinomas and MALT lymphomas. As for its cause, host-related factors (social factors as well as nutritional and environmental factors) are, besides various virulent strains, also named as causal factors. The recomLine Helicobacter 2.0 detects antibodies against ten selected Helicobacter pylori antigens. The detection of antibodies against the two most important virulence factors, CagA and VacA, is of high diagnostic significance. These two virulence factors markedly increase the risk of premalignant changes, gastric carcinoma, MALT lymphoma and ulcer. The humoral immune response to the biomarkers GroEL, HtrA, NapA, HP231 and CtkA is associated with a severe course of disease. The recomLine Helicobacter 2.0 is the first serological test to present this selection of diagnostically relevant Helicobacter pylori markers.
Sample Type Serum, plasma, whole blood
Assay Resolution See Figure
Components
10X Wash Buffer100 mL
TMB Substrate40 mL
Milk Powder5 g
Instuctions for Use1 Each
Evaluation Form1 Each
Test Strips2 Vials x 10 Each
Anti-Human IgG Conjugate500 uL
Positive Control140 uL
Negative Control140 uL
Specificity Information
Target Name Helicobacter markers: CagA, VacA, GroEL, FliD, HpaA, gGT, HtrA, NapA, HP231, CtkA
Target ID Human Helicobacter IgG
Alternative Names CagA, VacA, GroEL, FliD, HpaA, gGT, HtrA, NapA, HP231, CtkA
Research Areas Infectious Disease
Application Images
Description Test Strip Layout
Additional Information
Handling
Storage Store at 2 - 8°C until expiration on packaging.
References & Data Sheet