Myelin Oligodendrocyte Glycoprotein (24202P-50)
| Host | Quantity | Applications | Species Reactivity | Data Sheet | |
|---|---|---|---|---|---|
| 50ug | WB | Human |  |
Overview
Product Name Myelin Oligodendrocyte Glycoprotein (24202P-50)
Description Recombinant Human MOG produced in E. coli is a single non-glycosylated polypeptide chain containing 132 amino acids with a molecular weight of 15.2kDa. It is fused to a 6X His-tag at the C-terminus.Amino Acid Sequence:Met-GQFRVIGPRHPIRALVGDEVE LPCRISPGKNATGMEVGWYR PPFSRVVHLYRNGKDQDGDQ APEYRGRTELLKDAIGEGKV TLRIRNVRFSDEGGFTCFFR DHSYQEEAAM ELKVEDPFYWVSPG- HHHHHHPurity: Greater than 95% as determined by SDS- PAGE and RP-HPLC.
Target Myelin Oligodendrocyte Glycoprotein
Species Reactivity Human
Applications WB
Source Escherichia coli
Properties
Form Lyophilized
Formulation Reconstitute lyophilized MOG in sterile 50mM acetic acid to no less than 100ug/ml which can be further diluted in other aqueous solutions as needed.
Molecular Mass Molecular weight of 15.2 kDa
Purity Greater than 95% as determined by SDS- PAGE and RP-HPLC
Background Myelin Oligodendrocyte Glycoprotein (MOG) is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Given its localization, it is a prime target antigen of immune-mediated demyelination. MOG is involved in completion and maintenance of the myelin sheath and in cell-cell communication. MOG is differentially expressed in the dorsolateral prefrontal cortex and in the temporal lobe from patients with schizophrenia.
Specificity Information
Target Name Myelin-oligodendrocyte glycoprotein
Target ID Myelin Oligodendrocyte Glycoprotein
Alternative Names MOG
Sequence Location [Isoform 1]: Cell membrane , Multi-pass membrane protein , Multi-pass membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein
Sequence Met-GQFRVIGPRHPIRALVGDEVE LPCRISPGKNATGMEVGWYR PPFSRVVHLYRNGKDQDGDQ APEYRGRTELLKDAIGEGKV TLRIRNVRFSDEGGFTCFFR DHSYQEEAAM ELKVEDPFYWVSPG- HHHHHHPurityGreater than 95% as determined by SDS- PAGE and RP-HPLC.Accession numberQ16653
Biological Function Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. {PubMed:21880773}.
Background Myelin Oligodendrocyte Glycoprotein (MOG) is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Given its localization, it is a prime target antigen of immune-mediated demyelination. MOG is involved in completion and maintenance of the myelin sheath and in cell-cell communication. MOG is differentially expressed in the dorsolateral prefrontal cortex and in the temporal lobe from patients with schizophrenia.
Handling
Storage Although stable at room temperature for 3 weeks, the lyophilized product is best stored at or below -20°C. Upon reconstitution, product can be stored at 4°C for up to 1 week but is best stored at or below -20°C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long- term storage.
Dilution Instructions Reconstitute lyophilized MOG in sterile 10mM acetic acid to no less than 100ug/ml which can be further diluted in other aqueous solutions as needed.
References & Data Sheet
Data Sheet 
Download PDF Data Sheet
Download PDF Data Sheet