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Myelin Oligodendrocyte Glycoprotein (24202P-50)

$279.00

Host Quantity Applications Species Reactivity Data Sheet  
50ug WB Human
SKU: 24202P-50 Categories: ,
Overview
Product Name Myelin Oligodendrocyte Glycoprotein (24202P-50)
Description Recombinant Human MOG produced in E. coli is a single non-glycosylated polypeptide chain containing 132 amino acids with a molecular weight of 15.2kDa. It is fused to a 6X His-tag at the C-terminus.Amino Acid Sequence:Met-GQFRVIGPRHPIRALVGDEVE LPCRISPGKNATGMEVGWYR PPFSRVVHLYRNGKDQDGDQ APEYRGRTELLKDAIGEGKV TLRIRNVRFSDEGGFTCFFR DHSYQEEAAM ELKVEDPFYWVSPG- HHHHHHPurity: Greater than 95% as determined by SDS- PAGE and RP-HPLC.
Target Myelin Oligodendrocyte Glycoprotein
Species Reactivity Human
Applications WB
Source Escherichia coli
Properties
Form Lyophilized
Formulation Reconstitute lyophilized MOG in sterile 50mM acetic acid to no less than 100ug/ml which can be further diluted in other aqueous solutions as needed.
Molecular Mass Molecular weight of 15.2 kDa
Purity Greater than 95% as determined by SDS- PAGE and RP-HPLC
Background Myelin Oligodendrocyte Glycoprotein (MOG) is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Given its localization, it is a prime target antigen of immune-mediated demyelination. MOG is involved in completion and maintenance of the myelin sheath and in cell-cell communication. MOG is differentially expressed in the dorsolateral prefrontal cortex and in the temporal lobe from patients with schizophrenia.
Specificity Information
Target Name Myelin-oligodendrocyte glycoprotein
Target ID Myelin Oligodendrocyte Glycoprotein
Alternative Names MOG
Sequence Location [Isoform 1]: Cell membrane , Multi-pass membrane protein , Multi-pass membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein , Single-pass type I membrane protein
Sequence Met-GQFRVIGPRHPIRALVGDEVE LPCRISPGKNATGMEVGWYR PPFSRVVHLYRNGKDQDGDQ APEYRGRTELLKDAIGEGKV TLRIRNVRFSDEGGFTCFFR DHSYQEEAAM ELKVEDPFYWVSPG- HHHHHHPurityGreater than 95% as determined by SDS- PAGE and RP-HPLC.Accession numberQ16653
Biological Function Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. {PubMed:21880773}.
Background Myelin Oligodendrocyte Glycoprotein (MOG) is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Given its localization, it is a prime target antigen of immune-mediated demyelination. MOG is involved in completion and maintenance of the myelin sheath and in cell-cell communication. MOG is differentially expressed in the dorsolateral prefrontal cortex and in the temporal lobe from patients with schizophrenia.
Application Images
Additional Information
Handling
Storage Although stable at room temperature for 3 weeks, the lyophilized product is best stored at or below -20°C. Upon reconstitution, product can be stored at 4°C for up to 1 week but is best stored at or below -20°C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long- term storage.
Dilution Instructions Reconstitute lyophilized MOG in sterile 10mM acetic acid to no less than 100ug/ml which can be further diluted in other aqueous solutions as needed.
References & Data Sheet