Product Name Fibroblast Growth Factor-acidic (45101)
Description Recombinant Human Acidic Fibroblast Growth Factor
Target Fibroblast Growth Factor-acidic
Product Background Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1
Species Reactivity Human
Source Genetically-engineered E. coli
Concentration Lot Specific
Formulation 0.1% trifluoroacetic acid + 40% acetonitrile.
Molecular Mass Molecular Weight: 15,000 Da
Target Name Fibroblast Growth Factor-acidic
Target ID Fibroblast Growth Factor-acidic
Alternative Names rHuFGFa
Biological Activity Fibroblast Growth Factor-acidic
Storage Store at 2 - 8ºC. Do not Freeze.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.