Recombinant CXCL10 (IP-10)
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CXCL10, also known as γ-interferon-inducible protein (IP-10), was originally identified as an IFN- gamma-inducible gene in endothelial cells, fibroblasts, and monocytes. IP-10 signals through the CXCR3 receptor to attract Th1 lymphocytes and monocytes. It also has angiostatic and mitogenic properties on vascular smooth muscle cells. A diverse population of cell types rapidly increases transcription of mRNA encoding IP-10, suggesting that IP-10 might be a key mediator of the IFN-gamma response.
Source: Recombinant human CCL14 is produced in E. coli (accession no. P02778, aa 22-98).
Protein Sequence: VPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGE KRCLNPESKAIKNLLKAVSKERSKRSP
Molecular Mass: 8.646kDa by Mass Spec.
Purity: >97% by SDS-PAGE
Activity: EC50 = 6.3nM determined by Migration Assay in cells expressing recombinant CXCR3.
Endotoxin Level: <0.01 EU per 1ug of protein by LAL method. Form: Lyophilized. Carrier Protein: None.
PREPARATION AND STORAGE
Reconstitution: Recommended at 100ug/ml in sterile distilled water.
Stability and Storage: 12 months from date of receipt, -20°C to -70°C, as supplied.
1 month, -20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution.
Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in diagnostic or therapeutic procedures.