Anti-RAD17 Antibody (56229)

$362.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	WB	Human

SKU: 56229 Categories: Antibody Products, Cancer Research Antibodies, Products

Overview

Product Name Anti-RAD17 Antibody (56229)

Description Anti-RAD17 Rabbit Polyclonal Antibody

Target RAD17

Species Reactivity Human

Applications WB

Host Rabbit

Clonality Polyclonal

Immunogen Peptide corresponding to aa 2-15 of human RAD17.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by peptide immuno-affinity chromatography

Specificity This antibody recognizes human RAD17, a novel gene product involved in the DNA damage checkpoint signal transduction pathway. RAD17 plays a central role in cell cycle checkpoint control.

Target Name Cell cycle checkpoint protein RAD17

Target ID RAD17

Uniprot ID O75943

Alternative Names hRad17, RF-C/activator 1 homolog

Gene Name RAD17

Sequence Location Nucleus

Biological Function Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous rPubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12578958, PubMed:12672690, PubMed:14500819, PubMed:14624239, PubMed:15235112, PubMed:15538388, PubMed:21659603}.

Research Areas Cancer research

Handling

Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Dilution Instructions Dilute in PBS or medium which is identical to that used in the assay system.

Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution. A band of approx. 69 kD is detected.

Data Sheet