Rabies Virus Monoclonal Antibody
Catalog No.: 20501
Format: 200ug Protein G-purified antibody in PBS, pH 7.4, 0.09% sodium azide.
Rabies is a zoonotic infectious disease of the central nervous system. In unvaccinated or untreated subjects, rabies virus infection causes severe neurological symptoms and is usually fatal. Rabies virus has a bullet-shaped, enveloped virion with a negative-sense single-stranded RNA genome that encodes five viral proteins: nucleoprotein, phosphoprotein, matrix protein, glycoprotein, and RNA-dependent RNA polymerase. The virus attaches to its cellular targets by the surface glycoprotein (RABV-G), rapidly gains access to peripheral nerves, and ultimately reaches the brain. Transport of the enveloped virus within nerve cells and neuronal transport vesicles impedes clearance by humoral or cellular immunity.
Antigen: Russian rabies vaccine strain Vnukovo-32.
Host Species: Mouse
Clone No.: 1C5
Antibody Subtype: IgG2a
Specificity: This antibody recognizes rabies virus glycoprotein (UniProtKB Q08089) and neutralizes the following strains of rabies virus: CVS, Flury Lep, Flury HEP, Mokola 1, Mokola 2, Lagos bat, Duvenhage, and field isolates.
Immunohistochemistry Customer confirmed that #20501 works on formalin-fixed tissues with protease pre-treatment.
Immunoblotting Customer confirmed that #20501 detects viral glycoprotein in Western blot.
Endusers should determine optimal antibody concentrations for their applications.
Dilute in PBS or medium that is compatible with the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at 4ºC.
For in vitro investigational use only. Not intended for use in therapeutic or diagnostic procedures.