Anti-PSDR1 Antibody (34007)

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	WB,ELISA	Human

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SKU: 34007 Categories: Antibody Products, Cancer Research Antibodies, Products

Overview

Product Name Anti-PSDR1 Antibody (34007)

Description Anti-PSDR1 Rabbit Polyclonal Antibody

Target PSDR1

Species Reactivity Human

Applications WB,ELISA

Host Rabbit

Clonality Polyclonal

Immunogen N-terminal sequence MVELMFP and C-terminal sequence LLGLPID of human PSDR1.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS.

Buffer Formulation Phosphate Buffered Saline

Format Purified

Purification Purified by immunoaffinity chromatography

Specificity This antibody recognizes human PSDR1 (28 kD).

Target Name Retinol dehydrogenase 11

Target ID PSDR1

Uniprot ID Q8TC12

Alternative Names EC 1.1.1.300, Androgen-regulated short-chain dehydrogenase/reductase 1, HCV core-binding protein HCBP12, Prostate short-chain dehydrogenase/reductase 1, Retinal reductase 1, RalR1, Short chain dehydrogenase/reductase family 7C member 1

Gene Name RDH11

Sequence Location Endoplasmic reticulum membrane, Single-pass type II membrane protein

Biological Function Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956). {PubMed:12036956, PubMed:12226107, PubMed:15865448, PubMed:29410696}.

Research Areas Cancer research

Background Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate cancer. PSDR1 (prostate short-chain dehydrogenase- reductase 1) is a novel gene whose expression is increased following exposure of LNCaP cells to androgens. PSDR1 is highly expressed in the human prostate gland and is localized in both normal and neoplastic prostate epithelium. It has been suggested that PSDR1 may play a role in the pathogenesis of prostate cancer.

Handling

Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.

Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution

ELISA: use at 1:1,000-1:5,000 dilution.

Data Sheet