PSD95 Monoclonal Antibody
Catalog No.: 56457
Clone No.: 7E3-1B8
MAb Subtype: IgG1
Format: Protein G-purified antibody in PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
Postsynaptic Density Protein 95 (PSD95), also known as Synapse Associated Protein 90kDa, is a member of the membrane-associated guanylate kinase family of proteins. PSD95 is a scaffolding protein involved in the assembly and function of the postsynaptic density complex. This family of proteins consists of N-terminal variable segments followed by three amino-terminal PDZ domains, an upstream SH3 domain, and an inactive carboxy-terminal guanylate kinase domain. The first and second PDZ domains localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins, neuronal cell adhesion molecules. PSD95 also binds to neuronal nitric oxide synthase. PSD95 is implicated in experience-dependent plasticity and plays an indispensable role in learning. Mutations in PSD95 are associated with autism.
Antigen: Recombinant rat PSD95
Host Species: Mouse
Gene ID: 29495
Accession No.: NP_062567.1, P31016
Specificity: This antibody recognizes mouse, rat, pig, and human PSD95.
Immunoblotting: use at 1ug/ml. A band of ~100 kDa is detected.
Immunocytochemistry: use at 1-10ug/ml.
Immunofluorescence: use at10ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their application.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C.
For in vitro investigational use only. Not intended for therapeutic or diagnostic applications.