Anti-Prostaglandin E Synthase Antibody (13809)

$454.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	50ug	IHC,IHC-P	Human

SKU: 13809 Categories: Antibody Products, Enzymes and Enzyme Inhibitor Antibodies, Products

Overview

Product Name Anti-Prostaglandin E Synthase Antibody (13809)

Description Anti-Prostaglandin E Synthase Rabbit Polyclonal Antibody

Target Prostaglandin E Synthase

Species Reactivity Human

Applications IHC,IHC-P

Host Rabbit

Clonality Polyclonal

Immunogen Synthetic peptide conjugated to KLH.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS containing 0.1% sodium azide

Buffer Formulation Phosphate Buffered Saline

Buffer Anti-Microbial 0.1% Sodium Azide

Format Purified

Purification Purified by peptide immuno-affinity chromatography

Specificity This antibody recognizes an epitope near the N-terminus of human PGES.

Target Name Prostaglandin E synthase

Target ID Prostaglandin E Synthase

Uniprot ID O14684

Alternative Names EC 5.3.99.3, Glutathione peroxidase PTGES, EC 1.11.1.-, Glutathione transferase PTGES, EC 2.5.1.18, Microsomal glutathione S-transferase 1-like 1, MGST1-L1, Microsomal prostaglandin E synthase 1, MPGES-1, p53-induced gene 12 protein

Gene Name PTGES

Accession Number NP_004869.1

Sequence Location Membrane, Cytoplasm, perinuclear region

Biological Function Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). {UniProtKB:Q9JM51, PubMed:10377395, PubMed:10869354, PubMed:12244105, PubMed:12460774, PubMed:12672824, PubMed:18682561}.

Research Areas Enzymes

Background Prostaglandin E Synthase (PGES) is a membrane associated protein involved in eicosanoid and glutathione metabolism as part of the arachidonic acid signaling pathway. PGES expression is induced by the proinflammatory cytokine IL-1B, and its activity is glutathione dependent. PGES is also expressed at high levels in p53- expressing cells.