PMS2

 PMS2 Monoclonal Antibody 

ORDERING INFORMATION 

Catalog No. Clone No. Size 

34078 G412.1 100ul 

Format: Purified antibody in Tris buffer, pH 7.3-7.7, 1% BSA, <0.1% sodium azide. 

BACKGROUND 

Postmeiotic Segregation Increased 2 (PMS2) is a DNA repair protein involved in mismatch repair. Mutations and deficiencies in the PMS2 gene have been linked to microsatellite instability, malignancies such as hereditary nonpolyposis colorectal cancer, and endometrial cancer. Expression levels of the PMS2 protein may be useful as a screening tool for Lynch syndrome after a colorectal cancer diagnosis. 

DESCRIPTION 

Antigen: Recombinant human PMS2. 

Accession No.: P54278 

Gene ID: 5395 

Host: Mouse 

Antibody subtype: IgG1 

Specificity: Human PMS2. Reactivity with other species has not been investigated. 

APPLICATIONS 

Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. 

STORAGE AND STABILITY 

Store at 2-8ºC. Do not freeze. 

For in vitro investigational use only. Not for use in diagnostic or therapeutic applications.

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