Catalog No.: 1121
Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma- tography.
Glial cell line-derived neurotrophic factor (GDNF) plays a key role in the conrol of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. (NTN). Physiological responses to NTN require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRα. The cDNAS encoding NTNRα from human, rat, chicken, and mouse have been cloned and referred to as GFRα-2, GDNFRβ, Ret ligand 2 (RETL2), and TGF-β-related neurotrophic factor receptor 2 (TmR2). NTN forms a complex with GFRα-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations.
Antigen: Peptide corresponding to aa 178-193 of human neurturin.
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human, neurturin (14 kD).
Immunoblotting: use at 1:500 dilution.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.