Neuronal Cell Adhesion Molecule (NRCAM) Monoclonal Antibody
Catalog no.: 56581 (clone 343-26)
Format: 100ug (1mg/ml) Protein G-purified antibody in PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.
The NRCAM gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.
Antigen: Fusion protein corresponding to aa 30-845 (extracellular domain) of mouse NRCAM. This sequence is 96% identical in rat, 91% identical in human, and ~50% identical in Neurofascin. Accession nos: NP_001139503.1, Q810U4
Gene ID: 319504
Host Species: Mouse
Antibody Class: IgG2a
Specificity: This antibody recognizes human, mouse, and rat NRCAM.
Immunoblotting: use at 1-5ug/ml. A band of ~160kDa is detected.
Immunofluorescence: use at 10ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their application.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This product is stable for at least one (1) year at -20°C.
For in vitro investigational use only. Not intended for therapeutic or diagnostic procedures.