Neuroligin-3 Monoclonal Antibody
Catalog no.: 56552 (clone S110-29)
Format: 100ug (1mg/ml) Protein G-purified antibody in PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.
Neuroligin-3 is a neuronal cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. It plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. It may also promote the initial formation of synapses and play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Antigen: Fusion protein corresponding to aa 730-848 (intracellular C-terminus) of rat Neuroligin- 3. This sequence is 99% identical to mouse and 98% identical to human Neuroligin-3.
Accession nos.: AAA97871, Q62889
Gene Id: 171297
Host Species: Mouse
Antibody Class: IgG1
Specificity: This antibody recognizes human, mouse and rat Neuroligin-3. It does not cross- react with Neuroligin-1, -2, or -4.
Immunoblotting: use at 1-5ug/ml. A band of ~110kDa is detected.
Immunofluorescence: use at 10ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their application.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This product is stable for at least one (1) year at -20°C.
For in vitro investigational use only. Not intended for therapeutic or diagnostic procedures.