MTBP Polyclonal Antibody
Catalog No.: 56222
Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Antigen: Peptide corresponding to aa 122-139 of human MTBP. This sequence differs from that of mouse by three amino acids.
Host Species: Rabbit
Preservatives: 0.02% sodium azide
This antibody recognizes human and mouse MTBP which is involved in the p53 network of tumor suppression. p53 transcriptionally activates the MDM2 gene, then the translated MDM2 protein binds to p53 and promotes degradation of p53. MTBP binds to MDM2 and inhibits the modulating effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.
Immunoblotting: use at 0.5-1 ug/ml. In immunoblots, a band of 104 kD is detected.
Positive control: K562 cell lysate.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.