MSH2

 MSH2 Monoclonal Antibody 

ORDERING INFORMATION 

Catalog No. Clone No. Size 

34075 G410.1 100ul 

Format: Purified antibody in Tris buffer, pH 7.3-7.7, 1% BSA, <0.1% sodium azide. 

BACKGROUND 

MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability as well as endometrial and ovarian cancers. Anti-MSH2 antibody may be useful in the detection of the protein in a number of normal and neoplastic tissues and for identifying a loss of MSH2 in tumors that are microsatellite-unstable. 

DESCRIPTION 

Antigen: Recombinant human MSH2. 

Accession No.: P43246 

Gene ID: 4436 

Host: Mouse 

Antibody subtype: IgG2b 

Specificity: Human MSH2. Reactivity with other species has not been investigated. 

APPLICATIONS 

Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 6 for 10-30 minutes. 

STORAGE AND STABILITY 

Store at 2-8ºC. Do not freeze. 

For in vitro investigational use only. Not for use in diagnostic or therapeutic applications.

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