Mre11 Monoclonal Antibody
Catalog No.: 56211
Size: 100 ug Protein G-purified antibody in PBS, pH 7.4
Antigen: GST fusion protein corresponding to aa 182-582 of Mre11 expressed in E. coli.
Host Species: Mouse
Antibody Class: IgG1/κ
Preservatives: None. Available on request.
This antibody recognizes human Mre11, an 80 kD protein that acts as a Mn+2- dependent double stranded DNA 3’ to 5’ exonuclease and a single stranded DNA endonuclease. It is part of a larger complex with Rad50, p95 (Nibrin), and possibly other proteins involved in the nucleolytic end-processing of double strand breaks and telomere maintenance.
Immunoblotting, immunoprecipitation: use at 1-5 ug/ml.
Positive control: T24 cells, recombinant fusion protein.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -70°C. Avoid multiple freeze- thaw cycles.
Trujillo, KM et al. 1998. J Biol Chem 273: 21447-21450;
Carney, JP et al. 1998. Cell 93: 477-486;
Moreau, S et al. 1999. Mol Cell Biol 19: 556-566.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.