Anti-MMP 9 Antibody (29020)

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	WB	Human

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SKU: 29020 Categories: Antibody Products, Matrix Protein/MMP Antibodies, Products

Overview

Product Name Anti-MMP 9 Antibody (29020)

Description Anti-MMP9 Rabbit Polyclonal Antibody

Target MMP 9

Species Reactivity Human

Applications WB

Host Rabbit

Clonality Polyclonal

Immunogen Synthetic peptide corresponding to aa 540-552 of human MMP 9.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by immunoaffinity chromatography

Specificity This antibody specifically recognizes human MMP 9, a matrix metallo- proteinase produced by bone marrow- derived cells and believed to contribute to skin carcinogenesis.

Target Name Matrix metalloproteinase-9

Target ID MMP 9

Uniprot ID P14780

Alternative Names MMP-9, EC 3.4.24.35, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]

Gene Name MMP9

Sequence Location Secreted, extracellular space, extracellular matrix

Biological Function Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:2551898, PubMed:1480034, PubMed:12879005). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (PubMed:12879005). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed:1480034). Degrades fibronectin but not laminin or Pz-peptide. {UniProtKB:P41245, PubMed:12879005, PubMed:1480034, PubMed:2551898, PubMed:32883094}.

Research Areas Matrix/Metalloproteins

Handling

Storage This antibody is stable for at least one (1) year at -20°C to -70°C. Store antibody in appropriate aliquots to avoid multiple freeze-thaw cycles.

Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.

Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution. A band at 92 kD is detected.

Data Sheet