LRRK2 / Dardarin Monoclonal Antibody
Catalog no.: 56563 (clone S138-6)
Format: 100ug (1mg/ml) Protein G-purified antibody in PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.
LRRK2 is a large protein (>200kDa) with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Raslike small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. The LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. LRRK2 is also known as Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin, and PARK8.
Antigen: Fusion protein corresponding to aa 1-500 (N-terminus) of human LRRK2. This sequence is 83% identical in mouse and rat and has no significant identity to LRRK1.
Accession nos.: NP_940980, Q5S007
Gene ID: 120892
Host Species: Mouse
Antibody Class: IgG1
Specificity: This antibody recognizes human, mouse and rat LRRK2.
Immunoblotting: use at 1-5ug/ml. A band of >200kDa is detected.
Immunofluorescence: use at 10ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their application.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This product is stable for at least one (1) year at -20°C.
For in vitro investigational use only. Not intended for therapeutic or diagnostic procedures.