LRP4 (extracellular) Monoclonal Antibody
Catalog No.: 56540 (clone S207-27)
Size: 100ug in PBS (1mg/ml), pH 7.4, 50% glycerol, 0.09% sodium azide.
Purified by Protein G affinity chromatography.
The formation of neuromuscular junctions (NMJ) requires the interaction between motor neurons and muscle fibers. LRP4 (low-density lipoprotein receptor-related protein 4) is a receptor of agrin that is thought to act in cis to stimulate MuSK in muscle fibers for postsynaptic differentiation. Recent studies of muscle- specific mutants suggest that LRP4 is involved in determining where AChR clusters form in muscle fibers, postsynaptic differentiation, and axon terminal development.
Antigen: Fusion protein corresponding to aa 26-350 (extracellular N-terminus) of mouse LRP4 (accession no.Q8V156).
Host Species: Mouse
Antibody Class: IgG2a
This antibody recognizes mouse and rat LRP4.
Immunoblotting: use at 1ug/ml. Predicted molecular weight is ~215kDa. Degradation products of approx. 150kDa are also detected.
Positive Control: rat brain lysate.
These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid repeated freeze- thaw cycles.
For in vitro investigational use only. Not intended for diagnostic or therapeutic applications.