Catalog No.: 11006
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Apoptosis is prevented by the inhibitor of apoptosis (IAP) proteins. A novel member in the IAP protein family has been identified and designated Livin and KIAP for kidney IAP. Livin/KIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-a and Livin-b. Transfection of Livin in cells results in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6. Livin has direct interaction with several caspases including caspase-3, -7, and -9. Livin inhibits the activation of caspase-9 induced by Apaf- 1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.
Antigen: Peptide corresponding to aa 264- 280 of the short form and aa 281-298 of the long form of human Livin (accession no.
Host Species: Rabbit
Preservatives: 0.02% sodium azide
This antibody recognizes human Livin (33kDa).
Immunoblotting: use at 0.5-1.0ug/ml.
Positive control: Raji cell lysate.
Immunohistochemistry: use at 5ug/ml.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.