Catalog No.: 34008
Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma- tography.
Hippostatin, also known as KLK11, is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain- type and prostate-type. Hippostatin plays a role in the prostate, including reproductive and/or tumorigenic functions. Elevated serum levels of KLK11 were found in 70% of women with ovarian cancer and in 60% of men with prostate cancer. Analysis of the KLK11 biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma.
Immunogen: Synthetic peptide corresponding to aa residues 68-82 (YIVHLGQHNLQKEEG) of human
Hippostatin conjugated to KLH at the C- terminus.
Host Species: Rabbit
Preservatives: None. Available on request.
This antibody recognizes human hippostatin/KLK11 (35 kDa) which has 86% sequence homology with mouse and rat.
Immunoblotting : use at 1:500 dilution.
Positive control: LNCaP cell lysate
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Diamandis,E.P. et al. (2002) Cancer Res. 62: 295-300.
Nakamura,T et al. (2003) Prostate 54: 299-305.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.