Anti-KCNQ1 K+ Monoclonal Antibody
Catalog No.: 11510 (clone S37A-10)
Size: 100ug (1mg/ml) in PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. –+7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. K+7.1 is present in cell membranes of cardiac muscle tissue and in inner ear neurons among other tissues. In cardiac cells, K+7.1 mediates the I. (or slow delayed rectifying K3) current that contributes to repolarization of the cell, terminating the cardiac potential and, thereby, the heart’s contractions.
Antigen: Fusion protein aa 2-101 of human KCNQ1 (K+7.1, KvLQT1, accession number P51787).
Host Species: Mouse
Antibody Class: IgG1
This antibody recognizes human, mouse and rat KCNQ1.
Immunoblotting: use at 1-10ug/ml. A band of ~75kDa is detected.
Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml.
These are recommended concentrations; enduser should determine optimal concentrations for their applications.
Positive control: COS cell lysate transiently expressing KCNQ1.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid repeated freeze-thaw cycles.
For in vitro investigational use only. Not intended for diagnostic or therapeutic applications.