Anti-Inositol hexakisphosphate kinase 2 (IP6K2) Monoclonal Antibody
Catalog No.: 11018 (clone 4F10) Size: 100ug in PBS, pH 7.4, purified by Protein G affinity chromatography.
Inositol hexakisphosphate kinase 2 (IP6K2) catalyzes the production of diphosphoinositol pentakisphosphate (IP7) and has a role as a proapoptotic gene sensitizing cancer cells to apoptosis by cell stressors and anticancer drugs all of which depend on IP6K2 catalytic activity. IP6K2 is located in the 3p21.31 chromosomal region, which often undergoes allele loss in a variety of human cancers. Some heat shock proteins, especially Hsp90, can be antiapoptotic and the targets of anticancer drugs. Hsp90 binds IP6K2 and inhibits its catalytic activity. Drugs and selective mutations that abolish HSP90-IP6K2 binding elicit activation of IP6K2, leading to cell death. Thus, the prosurvival actions of HSP90 reflect the inhibition of IP6K2, suggesting that selectively blocking this interaction could provide effective and safer modes of chemotherapy.
Antigen: Full-length recombinant human IP6K2.
Host Species: Mouse
Antibody Class: IgG2b
This antibody recognizes human IP6K2.
Immunoblotting: A band of ~49 kDa is detected. User should determine optimal concentrations for their application.
Positive control: purified human IP6K2 or NIH-OVCAR-3 cells after treatment with interferon (IFN)-β.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid repeated freezing and thawing.
Morrison, BH et al. 2002 Oncogene 21: 1882-1889.